REVIEW ON FORMULATION AND EVALUATION OF SOLID LIPID NANOPARTICLES FOR VAGINAL APPLICATION

Vaginal drug administration can improve prophylaxis and treatment of many conditions affecting the female reproductive tract, which includes fungal bacterial infections, sexually transmitted diseases cancer also. This is best route for proteins, peptides, also other therapeutic drugs like macro-molecules. For contraceptives, steroids, metronidazole, anti-retroviral, vaginal delivery most preferable route. However, achieving sufficient concentration in vagina be challenging because its low permeability. The benefits system are it increases bioavailability, least systemic side effects; easiness use self-medication possible. However considered as a less effective unfortunate absorption across epithelium. traditional commercial preparations, such creams, foams, gels, irrigations tablets, known to reside cavity relatively short period time owing self-cleaning action tract often require multiple daily doses ensure desired effect. With rapidly developing field nanotechnology, specifically designed carrier systems Nanoparticle-based has been proven an excellent choice application overcome challenges associated with